Glycerol-induced injury results in impaired skeletal muscle regeneration of plasminogen-deficient mice.

(A) Frozen muscle sections from wild-type (WT) and Plg-deficient mice were stained with H&E 9 days after injury. In WT mice, regeneration is almost complete 9 days after injury, whereas it is impaired in Plg-deficient mice. (B) Immunohistochemical detection of fibrin in regenerating muscle of Plg-deficient mice. Sections from 9-day–injured muscles of WT and Plg-deficient mice were stained with a rabbit antimurine fibrin(ogen) antibody and counterstained with hematoxylin. Fibrin deposits were observed in regenerating muscle of Plg-deficient mice but not of WT mice. Original magnification, 400 ×.