Immunologic detection of fibrin in regenerating muscle of uPA-deficient mice.

Frozen cross-sections from regenerating muscle (9 days after injury) of wild-type (WT) mice and uPA-deficient mice (uPA−/−) were stained with a rabbit antimurine fibrin(ogen) antibody. Brown indicates positivity. Immunoperoxidase staining showed that fibrin deposits were abundant in uPA-deficient mice, but not in WT mice, at 9 days after injury. Original magnification, 400 ×.