Pedigree of the family with the inherited bleeding disorder.

Closed symbol indicates affected; open symbol, unaffected; and open symbol with ?, disease status unknown. The PT and aPTT are indicated after the generation and family number; ND indicates not determined. Genetic haplotypes are indicated for all individuals who were genotyped. The filled black bar indicates the haplotype cosegregating with the disease. Recombinations are indicated by open bars.