Fig. 2.
Fig. 2. Recombinant TIMP-1 induces IL-10 expression by a mechanism independent of inhibition of matrix metalloproteinases. / TIMP-1− JD38 cells were incubated in serum-free media with native recombinant TIMP-1 (A) and reduced and alkylated TIMP-1 (B) (destroys enzyme inhibitory but not growth factor activity) and secreted IL-10 measured by ELISA.

Recombinant TIMP-1 induces IL-10 expression by a mechanism independent of inhibition of matrix metalloproteinases.

TIMP-1− JD38 cells were incubated in serum-free media with native recombinant TIMP-1 (A) and reduced and alkylated TIMP-1 (B) (destroys enzyme inhibitory but not growth factor activity) and secreted IL-10 measured by ELISA.

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