Analysis of VEGF-induced vascular permeability in vivo.

VEGF-induced vascular permeability in BALB/c mice pretreated (30 minutes) with TAPI or solvent (A) or the SAPK-2/p38 specific inhibitor SB203580 (VEGF plus SB) or solvent (VEGF) (B). Shown are scatter diagrams with each symbol representing the ratio between the VEGF- and PBS-treated ear of one tested animal. Depicted are the mean (line) and the significance (P values) as calculated from an unpaired t test using a commercial program (InStat 2.01). Note the different y-axis scales. Although variations between the values of individual animals were observed, probably due to injuries of small capillaries during injections, the differences between the individual groups were highly significant.