Mobilization kinetics after single anti-integrin antibodies in mice and primates.

Mice were treated with 1 injection alone of anti-α4 (a-CD49d, clone PS/2) or a single injection of 2 different clones of anti-β2 (anti-CD18, clones GAME 46 and 2E6, upper panel). The monkeys were given 1 injection alone of anti-α4 (anti-CD49d, clone HP1/2 humanized) or anti-β2 (anti-CD18, clone 60.3, lower panel).