Mobilization by single and combined anti-integrin antibody treatments.

Mice were injected with antibodies at 2 mg/kg of body weight daily for 3 days and bled on the fourth day. Dark columns in the front row show mice treated with anti-CD11a (M17/4), anti-CD18 (GAME-46), and anti-CD49e (5H10-27). Data from these mice were compared with control mice (left, dark column) treated with phosphate-buffered saline plus bovine serum albumin. Lighter columns in the back row show data from combined (with anti-CD49d [PS/2]) antibody treatments compared with mice treated with anti-CD49d alone (left lighter column in back row). Anti-CD18 plus anti-CD49d was not statistically significant (P  > .1) in contrast to the other 2 combinations (P < .005). The bars on top of the columns show standard error of the mean.