Distribution of chelated radioiron in normal rats.

Control animals were injected intraperitoneally with⁵⁹Fe-citrate. In all other groups, ⁵⁹Fe was first bound in vitro to 10 mg of the chelator indicated and injected intraperitoneally. Measurements are at day 7. DFO indicates deferoxamine; ICL, ICL670A; DFO*+ICL, ⁵⁹Fe-DFO followed by 10 mg cold ICL670A; ICL*+DFO, ⁵⁹Fe-ICL670A followed by cold DFO. Each treatment group consisted of 4 animals (mean ± 1 SD). ▪ indicates blood; ⊠, liver; ■, fecal; and ▨, urine.