Fig. 5.
![Fig. 5. MDC, TARC, and SDF-1 cause increases in intracellular platelet [Ca2+]i in the presence of low levels of ADP. / INDO-1–loaded platelets21 were exposed to the chemokines (0.5 μg/mL) under low-shear conditions at 37°C, and fluorescence changes were monitored for several minutes. (A) MDC added to low levels of ADP (0.10 μM); second trace, MDC by itself; third trace, ADP by itself. (B) TARC added to ADP (0.10 μM); second trace TARC by itself. (C) SDF-1 added to ADP (0.10 μM); second trace SDF-1 by itself. The x-axis represents relative changes in [Ca2+]i,, and a 1-minute y-axis is also indicated.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/97/4/10.1182_blood.v97.4.937/5/h80410676005.jpeg?Expires=1724146492&Signature=OjNAkdihQKt5QnPigGAbk2~R0GqvIz6O1Rd-3fq-xB6ACnmPiFg5t0fjGALU7DTzjA01OOMzFylK7OEabSlBhs8jqXmg7xP1jVVj6tJ4YrAZvEcSrUIPGwyzSjKyZw~xlC4IIFndYomFt17z5fVNOLQpvhZINTOyIqSaHDS4zAATJ0RJoCB--DYiBH4Rlmlmgo~VpjWCqiSdzeXAu0eoocQpA8hJOcv83Vec1gbvHfFEzBLAmDxsOky7ZIheazY~~z9WRrhL3~f62-0sqoaF3s8AvNH13f7J-vQEMWIYLcoQilvxMwxsF61c6NvhTkNK9wtFS8jZPTLrre3xhn86FQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
MDC, TARC, and SDF-1 cause increases in intracellular platelet [Ca2+]i in the presence of low levels of ADP.
INDO-1–loaded platelets21 were exposed to the chemokines (0.5 μg/mL) under low-shear conditions at 37°C, and fluorescence changes were monitored for several minutes. (A) MDC added to low levels of ADP (0.10 μM); second trace, MDC by itself; third trace, ADP by itself. (B) TARC added to ADP (0.10 μM); second trace TARC by itself. (C) SDF-1 added to ADP (0.10 μM); second trace SDF-1 by itself. The x-axis represents relative changes in [Ca2+]i,, and a 1-minute y-axis is also indicated.
