Structural features of mDYRK kinases.

Upper panel: Cartoons depict mDYRK-3, mDYRK-2, mDYRK-1a, and mDYRK-1b, including conserved kinase subdomains, DYRK homology (DH) boxes, and, in mDYRK-1a, a PEST domain. Lower panel: Shown are Clustal W sequence alignments for mDYRK-3, mDYRK-2, mDYRK-1a, and mDYRK-1b. Indexed are DH boxes (boxed), predicted kinase subdomains I through XI (bracketed), and residues characteristic of DYRK kinases that in other kinases are rare at these positions (shaded residues).