Summary odds ratio of cancer recurrence24derived from randomized controlled trials investigating the association of perioperative allogeneic blood transfusion with cancer recurrence in patients undergoing elective colorectal cancer resection.2,21 22 

For each RCT, the figure shows the OR of cancer recurrence in recipients of buffy-coat–reduced allogeneic RBCs as compared with recipients of autologous whole blood21 or RBCs2or recipients of WBC-reduced allogeneic RBCs.22 Each OR is surrounded by its 95% CI. If the 95% CI of the OR includes the null value of 1, the TRIM effect is not statistically significant. The data are plotted on a logarithmic scale extending from 0.1 to 10.