Growth profiles of OI patients and controls from birth to the most recent assessment.

(A) Absolute growth in cm. (B) Growth velocity is defined as the difference between the first and last measurement of each interval, reported as a percentage of the median growth velocity for age- and sex-matched healthy children.21 Controls were children with OI who did not receive specific therapy during the observation period. Each symbol represents a crown-to-heel measurement. Arrows indicate the times of transplantation for patients (P).