Fig. 1.
Fig. 1. Schematic representation of idiotype adenoviral constructs. / In adenoviral plasmid transfer vector pXCJL1, heavy and light Ig chains are under the control of individual CMV promoters. The 38C13 VH and VL (Id) sequences are paired with murine γ2a heavy chain and κ light chain or human γ1 heavy chain and κ light chain sequences in viruses Ad-IdmuCR and Ad-IdhuCR, respectively. Ad-CTRLhuCR and Ad-BCL1huCR contain Ramos Id and BCL1 tumor Id sequences, respectively, along with human constant regions.

Schematic representation of idiotype adenoviral constructs.

In adenoviral plasmid transfer vector pXCJL1, heavy and light Ig chains are under the control of individual CMV promoters. The 38C13 VH and VL (Id) sequences are paired with murine γ2a heavy chain and κ light chain or human γ1 heavy chain and κ light chain sequences in viruses Ad-IdmuCR and Ad-IdhuCR, respectively. Ad-CTRLhuCR and Ad-BCL1huCR contain Ramos Id and BCL1 tumor Id sequences, respectively, along with human constant regions.

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