Correlation between CXCR-4 expression and mobilization of CD34⁺ cells per kilogram body weight during the first course of leukapheresis.

An exponential decrease of mobilized CD34⁺ cells is observed when the MFI of CXCR-4 on the CD34⁺ cells is higher. Linear regression analysis was performed with the natural logarithm (Ln) of the number of CD34⁺ cells as a dependent variable and MFI of CXCR-4 as an independent variable. The following function describes this model: CD34 = 18.062xe^{(−0.033 × (CXCR-4))}. The coefficient of CXCR-4 is significantly different from 0 (P < .0001). n = 54.