FGFR3 transformation can be inhibited by Raf-301 and Ras-N17.

NIH 3T3 cells were transfected in triplicate with 200 ng FGFR3 or with 50 ng Ras V12, in the presence of 4× molar excess of pCEFL, Raf 301, or Ras N17. Twelve to 14 days after transfection, the number of foci was counted and the percentage of inhibition by Ras N-17 or Raf-301 on the focus formation was calculated.