Effect of paclitaxel and carboplatin on normal hematopoietic progenitor cell growth in vitro.

Marrow CD34⁺ cells were exposed to paclitaxel (P) and carboplatin (C) alone or in combination and then cultured in the appropriate cytokines to yield BFU-E (A), CFU-GM (B), or CFU-Meg (C) colonies. Data derived from growth of 4 to 5 different donors, each cultured in quadruplicate, are shown.