Fig. 4.
Fig. 4. Model for P2X7-mediated ICE/caspase-1 activation and IL-1β maturation. / Stimulation with LPS triggers IL-1β gene transcription and pro–IL-1β accumulation. Opening of the P2X7 pore by extracellular ATP causes a large K+ efflux that triggers proteolytic activation of ICE and cleavage of pro–IL-1β. Mature IL-1β is then secreted through an unknown pathway.

Model for P2X7-mediated ICE/caspase-1 activation and IL-1β maturation.

Stimulation with LPS triggers IL-1β gene transcription and pro–IL-1β accumulation. Opening of the P2X7 pore by extracellular ATP causes a large K+ efflux that triggers proteolytic activation of ICE and cleavage of pro–IL-1β. Mature IL-1β is then secreted through an unknown pathway.

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