Effect of PAO on SDF-1α–induced chemotaxis of CXCR4 L1.2 and Jurkat cells.

CXCR4 L1.2 (A) or Jurkat (B) cells were pretreated with 0, 0.1, 0.3, or 1.0 μM concentration of PAO for 45 minutes. Migration toward 25 ng/mL SDF-1α was measured after 3 hours. Chemotaxis of cells in the absence of inhibitor is considered 100% migration. *P < .05; **P < .005.