Fig. 2.
Fig. 2. Heterogeneous expression pattern of BCL-6 and MUM1 proteins throughout the pathologic spectrum of systemic AIDS-NHL. / (A) Systemic AIDS-IBL displaying the BCL-6−, MUM1+, syn-1+, CD10−, LMP1+ phenotype (case 38, Table 1). In the figure, most immunoblastic-plasmacytoid tumor cells show nuclear immunoreactivity with the anti-MUM1 antibody. (B) Systemic AIDS-DLCL, displaying the BCL-6+, MUM1+, syn-1−, CD10−, LMP1− phenotype (case 29, Table 1). In the figure, large tumor cells show a nuclear staining pattern with anti-MUM1 antibody. (C) Systemic AIDS-BL displaying the BCL-6+, MUM1−, syn-1−, CD10+, LMP1− phenotype (case 6, Table 1). Neoplastic cells display strong nuclear immunoreactivity with the anti–BCL-6 mAb. Paraffin-embedded tissue sections, immunoperoxidase (A, B, C), hematoxylin counterstain. Original magnification, × 400 (A), × 250 (B, C).

Heterogeneous expression pattern of BCL-6 and MUM1 proteins throughout the pathologic spectrum of systemic AIDS-NHL.

(A) Systemic AIDS-IBL displaying the BCL-6−, MUM1+, syn-1+, CD10−, LMP1+ phenotype (case 38, Table 1). In the figure, most immunoblastic-plasmacytoid tumor cells show nuclear immunoreactivity with the anti-MUM1 antibody. (B) Systemic AIDS-DLCL, displaying the BCL-6+, MUM1+, syn-1−, CD10−, LMP1− phenotype (case 29, Table 1). In the figure, large tumor cells show a nuclear staining pattern with anti-MUM1 antibody. (C) Systemic AIDS-BL displaying the BCL-6+, MUM1−, syn-1−, CD10+, LMP1− phenotype (case 6, Table 1). Neoplastic cells display strong nuclear immunoreactivity with the anti–BCL-6 mAb. Paraffin-embedded tissue sections, immunoperoxidase (A, B, C), hematoxylin counterstain. Original magnification, × 400 (A), × 250 (B, C).

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