Fig. 7.
Fig. 7. The specificities of caspase inhibitors are best revealed at lower range of functional concentrations. / FA-C HSC536N lymphoblasts were exposed to IFN-γ and an agonistic anti-fas antibody for 180 minutes in the presence of either 0.1 to 5.0 μmol/L cell-permeable aldehyde inhibitors to caspases 1 and 4 (CP-YVAD-cho) and 3 (CP-DEVD-cho) (A), or 0.1 to 50 μmol/L FMK inhibitors to caspases 3 (DEVD-FMK), 8 (IETD-FMK), 1 and 4 (YVAD-FMK), 1 (WEHD-FMK) (B), or a negative control (Z-FA-FMK).

The specificities of caspase inhibitors are best revealed at lower range of functional concentrations.

FA-C HSC536N lymphoblasts were exposed to IFN-γ and an agonistic anti-fas antibody for 180 minutes in the presence of either 0.1 to 5.0 μmol/L cell-permeable aldehyde inhibitors to caspases 1 and 4 (CP-YVAD-cho) and 3 (CP-DEVD-cho) (A), or 0.1 to 50 μmol/L FMK inhibitors to caspases 3 (DEVD-FMK), 8 (IETD-FMK), 1 and 4 (YVAD-FMK), 1 (WEHD-FMK) (B), or a negative control (Z-FA-FMK).

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