Fig. 5.
![Fig. 5. Released BLyS induces B-cell proliferation and IgG production. / (A) [3H]thymidine incorporation by B cells was assessed after a 4-day culture with serial dilutions of U937-conditioned medium (indicated by a closed circle) in presence of the neutralizing mAb 15C10 (indicated by an open circle) or an unrelated mAb of the same isotype (indicated by closed triangles). Anti-IgM was added to the culture as costimulus. [3H]thymidine incorporation of B cells in the presence of anti-IgM was 630 dpm. (B) Purified B cells were cultured for 10 days with SAC and serial dilutions of the U937-conditioned medium in the absence or presence of mAb 15C10. IgG production was evaluated by ELISA.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/97/1/10.1182_blood.v97.1.198/6/h80110564005.jpeg?Expires=1722780306&Signature=SKFDWNaLC6X1oyHGGRjgoG0OiGw1XjNva-iwLDT-l8U94w0h~enmP2~~uUbdQ-geq2zyjlT1zx48sFZdiBOHtjR91eGu-v8YBKp8QtYewsw9g3LL-nLsU9Pl--kuZisRkVn4ogyLbBfF~rRjR0LRTQ~3DctvTg2r4LoOGpSeIzWdcXr3OA-1g11hvcN0broWxOsmDHx013KCra6gp-bWBJIn2XHssrV98~D6rUWoc3bKnjjHTV0WrG3za~Lnvcb6Wb69Ho2n5KhAWg1m0ixxT8keQEhQ8oyKW1jGJyeCl-W8ScGIpzvgtUNW4aUTEbGsdufHpr9PnEklxG6ebMaylg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Released BLyS induces B-cell proliferation and IgG production.
(A) [3H]thymidine incorporation by B cells was assessed after a 4-day culture with serial dilutions of U937-conditioned medium (indicated by a closed circle) in presence of the neutralizing mAb 15C10 (indicated by an open circle) or an unrelated mAb of the same isotype (indicated by closed triangles). Anti-IgM was added to the culture as costimulus. [3H]thymidine incorporation of B cells in the presence of anti-IgM was 630 dpm. (B) Purified B cells were cultured for 10 days with SAC and serial dilutions of the U937-conditioned medium in the absence or presence of mAb 15C10. IgG production was evaluated by ELISA.
