Plasma liver enzyme analyses.

Plasma was collected from the dogs at the indicated times prior to and following vector treatment and assessed for the presence of the liver enzyme ALT. (A) ALT analyses of dogs that received the higher vector dose (3 × 1012 particles/kg). (B) ALT analyses of dogs that received the lower vector dose (6 × 1011particles/kg). Pretreatment ALT value for dog A was 54 U/mL; at 22 months, ALT was 69 U/mL. Pretreatment ALT value for dog B was 47 U/mL; at 22 months, ALT was 55 U/mL. Pretreatment ALT value for dog C was 46 U/mL; at 16 months, ALT was 33 U/mL. Pretreatment ALT value for dog D was 44 U/mL; at 16 months, ALT was 47 U/mL.