Plasma FVIII expression levels in treated hemophilic dogs.

Plasma was collected from the dogs at the indicated times prior to and following vector treatment and assessed for FVIII biologic activity. (A) One-stage FVIII coagulant assay (APTT) plasma analyses from dogs treated with the higher vector dose (3 × 1012particles/kg). (B) Coatest bioassay plasma analyses from dogs treated with higher vector dose (3 × 1012 particles/kg). (C) One-stage FVIII coagulant assay (APTT) plasma analyses from dogs treated with the lower vector dose (6 × 1011particles/kg). (D) Coatest bioassay plasma analyses from dogs treated with the lower vector dose (6 × 1011particles/kg).