Survival curves of Bcr-Abl mice and SH2 mutant mice.

BM cells transduced by titer-matched viruses carrying thebcr-abl gene or its SH2 mutants as indicated were transplanted into recipient mice. Viral constructs and number of mice used in this representative experiment: bcr-abl, ▪, n = 13; bcr-abl/R1057K, ●, n = 15; bcr-abl/ΔSH2, ▴, n = 11. The survival curves were generated through Kaplan-Meier survival analysis.