Fig. 9.
Fig. 9. Inhibition of multinuclear osteoclast formation by blocking antibody against αv and β3integrin. / c-Fms+RANK− cells (1 × 103) were cultured with M-CSF and sRANKL with blocking antibodies against various integrins. After 6 days of culture, the number of multinuclear TRAP+ cells was scored. Note that the number of multinuclear cells was significantly reduced in the presence of anti–αv- and/or anti–β3-blocking antibodies compared to isotype-matched control.

Inhibition of multinuclear osteoclast formation by blocking antibody against αv and β3integrin.

c-Fms+RANK− cells (1 × 103) were cultured with M-CSF and sRANKL with blocking antibodies against various integrins. After 6 days of culture, the number of multinuclear TRAP+ cells was scored. Note that the number of multinuclear cells was significantly reduced in the presence of anti–αv- and/or anti–β3-blocking antibodies compared to isotype-matched control.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal