SDF-1–induced chemotaxis is impaired in WAS CD3⁺ lymphocytes.

The migration of PBMCs from normal donors or WAS patients in response to SDF-1 (300 ng/mL) was studied in a Transwell assay. Data representing the percentage of migrating CD3⁺ cells are expressed as the mean of triplicate ± SE. No differences were observed between patients' and controls' CD3⁺ cells in the absence of SDF-1 (range 0.3%-0.5% migrating cells) (not shown). (▪), patients; (▨), normal donors.