Diagrammatic representation of the ELL and MLL proteins.

(A) Sequence alignment of ELL and its closely related family member, ELL2, shows homology over their carboxyl-terminal sequences. (B) The MLL gene, located at chromosomal band 11q23, encodes a 3969-amino acid protein with A-T hooks (AT), 2 nuclear localization sequences (NLS), methyltransferase-like domain (MT), PHD-type zinc fingers, and a carboxy-terminal SET domain. ELL comprises 4 distinct domains (R1-R4) described in the text. Translocation t(11;19)(q23;p13.1) joins amino terminal regions of MLL to domains R2-R4 of ELL.