Laboratory course of 2 patients coinfected with HCV and HIV whose HCV viremia was resolved after immune improvement with HAART.

Serum viral RNA levels and various immunologic values were measured as described in Figure 1. ∗ and indicate that the viral RNA level was below the respective detection limit (0.5 × 10⁶ Eq/mL for HCV; 400 copies/mL for HIV). When the HCV RNA level was below the limit, nested RT-PCR was performed. Serial changes in serum HCV and HIV RNA levels (● and ○, respectively), peripheral B-cell and CD4⁺-cell counts (▪ and ■, respectively), and serum ALT concentrations (▴) are indicated. Antiretroviral drugs are abbreviated as follows: IDV, indinavir; d4T, stavudine; 3TC, lamivudine; ZDV, zidovudine.