Mean serum viral RNA levels and immunologic parameters in serial determinations in 35 HIV-infected patients treated with HAART.

Twenty-five of 29 hemophiliac patients infected with both HCV and HIV (●) and all 10 HCV-negative, HIV-positive patients (○) were treated with HAART, and underwent follow-up examinations before and at 6 and 12 months after initiation of HAART. Serum viral RNA levels and various immunologic parameters were measured as described in Figure 1. When the viral RNA level was below the detection limit of the quantitative assays (0.5 × 10⁶ Eq/mL for HCV; 400 copies/mL for HIV), the value was taken to be equal to the limit. Serial changes of serum HCV and HIV RNA levels (A,B), peripheral B-cell and CD4⁺-cell counts (C,D), serum immunoglobulin levels (E, IgG; F, IgA; G, IgM), and serum ALT levels (H) are indicated as means and SE.