Hodgkin-like ALCL.

(A-D) Hodgkin-like ALCL, ALK⁺. (A) Morphology at low magnification (hematoxylin and eosin). Note the nodular sclerosis. (B) Same case as in (A) at higher magnification. The large tumor cells resemble Hodgkin- and Reed-Sternberg cells. (C) Same case as in (A) immunostained for EMA (antibody clone E29). All tumor cells are labeled. (D) Same case as in (A) immunostained for ALK (antibody clone ALK1). The tumor cells show a strong positivity of their cytoplasm. (E,F) Hodgkin-like ALCL, ALK⁻. (E) Morphology by Giemsa stain. (F) Immunoreactivity for CD30 (antibody clone Ber-H2; alkaline phosphatase–antialkaline phosphatase). All tumor cells are strongly CD30-positive, but ALK-negative (not shown).