RhD protein sequences that stimulate T cells from alloimmune donors to proliferate are not limited to extracellular loops.

The predicted topographic features of the RhD protein5,6illustrate the location of the 4 dominant RhD peptides that elicited proliferation by T cells from most of the alloimmune donors. Residues within dominant peptides, ● (peptide 6 aa52-66, peptide 13 aa97-111, peptide 17 aa117-131, and peptide 28 aa177-191).