Fig. 5.
Development of leukemia-like disease in 32D/Flt3-ITD–injected mice.
Female C3H/HeJ mice, aged 8 to 10 weeks, were used for the in vivo tumorigenesis experiments. The 1 × 106 cells were inoculated intravenously. The figure shows an animal at autopsy 28 days after injection of 32D cells containing ITD2. (A) The abdomen of the mouse showing a grossly enlarged liver. (B) The explanted spleen (right) is shown; for size comparison, the spleen of an uninjected animal (left) was photographed simultaneously. (C) Bone marrow smear, Pappenheim stain.
