Fig. 6.
Fig. 6. Comparison of the immunotherapy achieved against BCL1 with anti-Id IgG and BsAb. / Groups of 5 huCD64+ age-matched mice received the treatment schedule shown in Figure 3. However, mice were inoculated with 105 BCL1 tumor cells intraperitoneally on day 0 and were treated with twice-daily doses of (a) 0.1, (b) 1, (c) 10, or (d) 100 μg mAb or BsAb intraperitoneally on days 1 to 5 (either 1, 10, 100, or 1000 μg in total/mouse). Treatment was as indicated: PBS (●), anti-Id IgG (▵), or [huCD64 × Id] BsAb (○). Symbols on plots show antibody specificity. Survival was recorded daily, and similar results were obtained in at least 3 similar experiments.

Comparison of the immunotherapy achieved against BCL1 with anti-Id IgG and BsAb.

Groups of 5 huCD64+ age-matched mice received the treatment schedule shown in Figure 3. However, mice were inoculated with 105 BCL1 tumor cells intraperitoneally on day 0 and were treated with twice-daily doses of (a) 0.1, (b) 1, (c) 10, or (d) 100 μg mAb or BsAb intraperitoneally on days 1 to 5 (either 1, 10, 100, or 1000 μg in total/mouse). Treatment was as indicated: PBS (●), anti-Id IgG (▵), or [huCD64 × Id] BsAb (○). Symbols on plots show antibody specificity. Survival was recorded daily, and similar results were obtained in at least 3 similar experiments.

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