Effects of FXa and thrombin on PDGF-BB–induced chemotaxis in human fibroblasts.

Cells were preincubated with 100 nmol/L FXa in the absence (▪) or presence (■) of 200 nmol/L TAP and with 100 nmol/L thrombin in the absence (●) or presence (○) of 15 U/mL Hirudin. TAP and Hirudin were present at all times during the experiments. Chemotaxis was induced by different concentrations of PDGF-BB. Results are mean ± SEM of 3 separate experiments.