Influence of FXa on the chemotactic response to PDGF-BB induced by FVIIa.

Fibroblasts were preincubated with 200 nmol/L TAP (▪) and then with 100 nmol/L FVIIa (●). TAP was present at all times during the experiments. Chemotaxis was induced by different concentrations of PDGF-BB. Results are mean ± SD of 2 separate experiments. Increased concentrations of TAP, 0.2 to 10 μmol/L, gave the same results (data not shown).