Influence of different concentrations of FVIIa or FFR-FVIIa on PDGF-BB–induced chemotaxis in fibroblasts.

▪ shows migration of fibroblasts to different concentrations of PDGF-BB alone. Cells were incubated with 12.5 (A), 25 (B), 50 (C) and 100 (D) nmol/L FVIIa (●) or FFR-FVIIa (○) and assayed in the Boyden chamber to different concentrations of PDGF-BB. Results are mean ± SEM of 3 different experiments. *P < .05; **P < .01; ***P < .001 (Studentt tests).