Effects of FVIIa and FFR-FVIIa on PDGF-BB–induced chemotaxis.

Effects of FVIIa and FFR-FVIIa on PDGF-BB–induced chemotaxis in human fibroblasts (A) and human aortic SMC (B). ▪ shows the chemotactic response of cells to different concentrations of PDGF-BB. Cells incubated with 100 nmol/L FVIIa (●) or 100 nmol/L FFR-FVIIa (○) migrated to different concentrations of PDGF-BB. Results are means± SEM of 3 separate experiments (A) or mean± SD of 2 separate experiments (B). *P < .05 was considered statistically significant (Student t test); **P < .01; ***P < .001. The same migration response to PDGF-BB was obtained with coronary artery SMC (data not shown).