Effect of Thal and analogs on DNA synthesis of MM cells resistant to conventional therapy.

Dox-resistant Dox6 (A) and Dox 40 (B), Mit-resistant (MR20; C), and Mel-resistant (LR5; D) cells were cultured with control media (■) or 1 μmol/L (▧), 10 μmol/L (▤), 100 μmol/L (▪) of Thal, IMiD1, IMiD2, or IMiD3. Values represent the mean (± SD) ³H-TdR (cpm) of triplicate cultures. (E) Dex-resistant MM.1R cells were cultured in control media (■) or with 0.1 μmol/L (▧), 1 μmol/L ([▤), 10 μmol/L (▨), or 100 μmol/L (▪) of Thal, IMiD1, IMiD2, or IMiD3.