IL-4–induced eotaxin generation in rat pleural cavities.

RPMI (100 μL/cavity; ■) or IL-4 (5000 units/100 μL per cavity; ▪) was injected into rat pleural cavities, and eotaxin levels in pleural exudates were quantified 4 or 24 hours later. Eotaxin generation is expressed in femtomoles per cavity and presented as the mean ± SEM value for 4 or 5 animals. A significant difference (P < .001) from levels in RPMI-treated rats is indicated by 2 asterisks.