Sebastian B family pedigree and typing for 10 chromosome 22 markers.

Circles represent females, and squares represent males. Open symbols denote unaffected family members; closed symbols denote affected family members. Critical recombination in family member III-1 define a 3-1-1-2-1-5-5-3 haplotype that is coinherited with the disease and that is not shared by the unaffected family members.