Italian Fechtner family pedigree and typing for 8 chromosome 22 markers.

Circles represent females, and squares represent males. Open symbols denote unaffected family members; closed symbols denote affected family members. Critical recombinations in family members II-4, III-2, III-8, IV-1, and IV-2 define a 2-6-2-4-2-1 haplotype that is coinherited with the disease and that is not shared by the unaffected family members.