Fibrinogen deficiency does not prevent the initial arrest of circulating tumor cells in lung tissue but diminishes sustained adherence or survival.

LLC cells labeled with 5-(¹²⁵I)iodo-2′-deoxyuridine were injected into the lateral tail vein of fibrin(ogen)-deficient (white bars) and control mice (hatched bars). The mice were killed at the specified time points and the amount of radioisotope in the lungs was measured. The data presented are median values and are expressed as percent of injected dose (1 × 10⁵ cells/77 000 cpm); n = number of mice. The P values were determined by the Mann-Whitney U test, 2 tailed.