The proaggregatory effect of CLHb was not attenuated by superoxide dismutase (SOD) and catalase.

Impedance aggregometry was performed on rabbit whole blood stimulated with collagen (1 μg/mL) in the presence or absence of superoxide dismutase (200 U/mL), catalase (200 U/mL), and CLHb (50 g/L). The Δ aggregation is the aggregation amplitude in the presence of the test substances minus that observed in Ringer's lactate alone, measured 6 minutes after the addition of the agonist (n = 10 data pairs per treatment arm). The data shown are means; error bars represent 1 SD. *P < .001 compared with results with Ringer's lactate alone.