CLHb infusion did not produce increased thrombin generation in vivo.

Plasma thrombin-antithrombin concentrations were measured before (open bars) and 1 hour after (solid bars) a bolus infusion ofo-raffinose CLHb or 5% HSA or a continuous infusion of thromboplastin in rats (n = 6 per treatment arm). The data are expressed as means; error bars denote 1 SD. *P < .001 compared with preinfusion value.