Extent of vasoconstriction induced by CLHb and Phen.

Changes in microvascular ear perfusion in rabbits given an infusion ofo-raffinose CLHb (solid circles; n = 6), 5% HSA (open squares; n = 6), or Phen (open triangles; n = 5) were measured by using a laser Doppler flowmeter. Baseline microvascular perfusion was that observed before infusion of the test substances. The solid bar indicates the period of infusion of the test substance (either CLHb or HSA), “A” denotes the time of administration of anesthesia, and the open bar denotes the period of ear immersion into the 37°C saline bath for bleeding-time testing. Phen was administered as an intravenous bolus followed by continuous infusion for the duration of the experiment. The data shown are means; error bars denote 1 SD.