Cross-linked hemoglobin (CLHb) shortened the microvascular bleeding time in anemic rabbits.

Microvascular bleeding times were measured in anemic rabbits 1 hour after infusion (left panel) of o-raffinose CLHb, 5% human serum albumin (HSA), phenylephrine (Phen), or nothing (0). For the CLHb and HSA groups, bleeding-time assessments were repeated 24 hours after infusion (right panel). The data are expressed as means; error bars denote 1 SD. *P < .001 compared with HSA, Phen, and results in untreated anemic rabbits at 1 hour; P < .001 compared with HSA at 24 hours.