Landmark analyses of bone marrow and blood.

Solid symbols indicate presence of a clonal marker indicative of lymphoma; open symbols indicate absence of clonal markers. Only informative markers are shown. (A) Landmark analysis of serial bone marrow samples from 20 patients with informative markers monitored by polymerase chain reaction (PCR) for clonal immunoglobulin heavy-chain rearrangements (circles), the t(14:18) translocation (squares), and the t(11;14) translocation (triangles). (B) Landmark analysis of serial peripheral blood samples from 13 patients with informative markers monitored by PCR for clonal immunoglobulin heavy-chain rearrangements (circles), the t(14:18) translocation (squares), and the t(11;14) translocation (triangles).