Fig. 2.
![Fig. 2. The inhibitory effects of ADP scavengers on serotonine secretion evoked by FcγRIIA is reversed by epinephrine. / Platelets were previously loaded with 5-hydroxy[14C]tryptamine, and secretion was determined as described in “Materials and methods.” A3P5PS, CP-CPK, and CP-CPK and 1-μmol/L epinephrine were added 1 minute before stimulation by FcγRIIA cross-linking. The effect of 1-μmol/L epinephrine alone was also assessed. Data are the mean of 2 independent experiments. (A) Stimulation by FcγRIIA cross-linking; (B) stimulation by HIT sera.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/96/10/10.1182_blood.v96.10.3439/5/h82200374002.jpeg?Expires=1722724521&Signature=3wlJrtoMaykmIsKtJKovzpOrQuv9qxHMqIhQj9sK4~0T6PiKmy0kAD~mK6TGmCdp7tGRHl6OljFCzjzZnbn-p8slWgOfUFy10wMlvSDXGxdhZ25kKm9GO5NOrykYRjL3uRop6X-KlIn-j0qgX3eJSwa9D~ZmjNVatngMszWTu4OAdrgRDIrlq4nz9kv5QixPvPVX4iN5A49YjW6eDyz6WOiIsovQVqoAve~33no~BCZjPMIfVWKZ9prTxJnCB9-9Um0NcrOnce5-o7yq~oq5PfgMon0kEZF3m~pcFBhfVVcvzoUmcW8LRP9-oPW9iOKqJwxqcswF6aDctH1slNGbVQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The inhibitory effects of ADP scavengers on serotonine secretion evoked by FcγRIIA is reversed by epinephrine.
Platelets were previously loaded with 5-hydroxy[14C]tryptamine, and secretion was determined as described in “Materials and methods.” A3P5PS, CP-CPK, and CP-CPK and 1-μmol/L epinephrine were added 1 minute before stimulation by FcγRIIA cross-linking. The effect of 1-μmol/L epinephrine alone was also assessed. Data are the mean of 2 independent experiments. (A) Stimulation by FcγRIIA cross-linking; (B) stimulation by HIT sera.
