Tyrosine phosphorylation, ERK, and p38 MAPK play roles in nonopsonic PE phagocytosis.

Monocytes were pretreated with genistein (10 μg/mL), PD98059 (50 μmol/L), SB203580 (30 μmol/L), or piceatannol (30 μg/mL) for 1 hour at room temperature, and PE phagocytosis was evaluated as before. Cumulative data from at least 4 independent experiments are presented as mean ± SEM; n ≥ 6 per group. **, P < .01; ***, P < .001 vs PEs (ANOVA with post hoc Tukey).