Analysis by FISH using the cCMP21 probe.

Patients 3 to 6 and 12 are at diagnosis (A to E) and patient 12 in AML evolution (F). Patients 3 to 6 showed 2 green spots, corresponding to 2 copies of chromosome 21 in each cell: interphase cells for patients 3 and 4 (A and B) or metaphase cells for patients 5 and 6 (C and D). At diagnosis, patient 12 presented 3 spots in each cells (E) and 2 spots in AML evolution (F).